Galectin-1/LGALS1 Antibody

Galectin-1/LGALS1 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • USA
  • 2025年10月16日
  • W
  • Rabbit
  • H,M,R,Mk
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    • 详细信息
    • 技术资料
    • 抗体英文名

      Galectin-1/LGALS1 Antibody

    • 抗原

      synthetic peptide corresponding to residues surrounding Leu33 of human galectin-1 protein

    • 应用范围

      W

    • 宿主

      Rabbit

    • 库存

      大量

    • 级别

      详见MSDS文件

    • 保质期

      详见说明书

    • 供应商

      CST

    • 适应物种

      H,M,R,Mk

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W H M R (Mk) Endogenous 15 Rabbit
    Protocols
    Specificity / Sensitivity

    Galectin-1/LGALS1 Antibody detects endogenous levels of total galectin-1 protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu33 of human galectin-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from HL-60 and THP-1 cells using Galectin-1/LGALS1 Antibody.

    Background

    Galectins are a family of β-galactose binding proteins that are characterized by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and their carbohydrate-binding site (1,2). Members of the galectin family have been implicated in a variety of biological functions including cell adhesion (3), growth regulation (4), cytokine production (5), T-cell apoptosis (6), and immune responses (7). Galectin-1 (LGALS1) has been shown to be expressed in a wide range of tissues and cell types. The level and pattern of expression of galectin-1 has been shown to change during development (8). In addition to its apparent role in developmental processes, galectin-1 has been shown to be involved in central immune tolerance and may function in tumorigenesis by modulating the immune response to the tumor (9,10). Research studies have shown that galectin-1 expression is increased in several human cancers, suggesting a correlation with metastatic potential (10).

    1. Barondes, S.H. et al. (1994) Cell 76, 597-8.
    2. Barondes, S.H. et al. (1994) J Biol Chem 269, 20807-10.
    3. Offner, H. et al. (1990) J Neuroimmunol 28, 177-84.
    4. Wells, V. and Mallucci, L. (1991) Cell 64, 91-7.
    5. Filer, A. et al. (2009) Arthritis Rheum 60, 1604-14.
    6. Perillo, N.L. et al. (1995) Nature 378, 736-9.
    7. Cooper, D.N. et al. (1991) J Cell Biol 115, 1437-48.
    8. Puche, A.C. et al. (1996) Dev Biol 179, 274-87.
    9. van den Brûle, F. et al. (2003) Lab Invest 83, 377-86.
    10. Salatino, M. et al. (2008) Expert Opin Biol Ther 8, 45-57.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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