PGAM1 Antibody

PGAM1 Antibody

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  • 询价
  • Cell Signaling Technology已认证
  • 7534
  • USA
  • 2025年10月05日
  • W
  • Rabbit
  • H,M,R,Mk
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    • 详细信息
    • 技术资料
    • 抗体英文名

      PGAM1 Antibody

    • 抗原

      synthetic peptide corresponding to residues surrounding Pro128 of human PGAM1 protein

    • 应用范围

      W

    • 宿主

      Rabbit

    • 保质期

      详见说明书

    • 适应物种

      H,M,R,Mk

    • 库存

      大量

    • 级别

      详见MSDS文件

    • 供应商

      CST

    • 是否单克隆

      2

    • 保存条件

      -20°c

    • 规格

      100 ul (10 western blots)/carrier free & custom formulation / quantity

    规格:产品价格:¥请询价
    规格:100 ul (10 western blots)产品价格:¥请询价
    规格:carrier free & custom formulation / quantity产品价格:¥请询价

    pathway more info application references datasheet PDF MSDS PDF protocols

    Applications Key:  W=Western Blotting
    Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Monkey
    Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.

    Applications Reactivity Sensitivity MW (kDa) Source
    W H M R Mk Endogenous 28 Rabbit
    Protocols
    Specificity / Sensitivity

    PGAM1 Antibody recognizes endogenous levels of total PGAM1 protein.

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro128 of human PGAM1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Western Blotting

    Western Blotting

    Western blot analysis of extracts from various cell lines using PGAM1 Antibody.

    Background

    Phosphoglycerate mutase (PGAM1) catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis (1-5). Increased PGAM1 expression has been implicated as a biomarker for cancer (1-4) and mental disease (5). Specifically, PGAM1 was shown to be phosphorylated at His11 by phosphoenolpyruvate (PEP) in PKM2-expressing cells, suggesting a possible regulatory role for PGAM1 in actively proliferating cells via an alternative glycolytic pathway (1).

    1. Vander Heiden, M.G. et al. (2010) Science 329, 1492-9.
    2. Jacobowitz, D.M. et al. (2008) Microvasc Res 76, 89-93.
    3. Ren, F. et al. (2010) Mol Cancer 9, 81.
    4. Evans, M.J. et al. (2005) Nat Biotechnol 23, 1303-7.
    5. Martins-de-Souza, D. et al. (2009) BMC Psychiatry 9, 17.
    Application References

    Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know !

    Companion Products

    For Research Use Only. Not For Use In Diagnostic Procedures.

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