TAB2 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 with TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.
克隆类型:
Mouse Monoclonal Antibody
亚型:
Mouse IgG1
免疫原:
Purified recombinant fragment of human TAB2 expressed in E. coli.
适用物种:
H
应用范围:
E, WB, FC
应用说明:
E: 10000; WB: 1:500-1:2000; FC: 1:200-1:400
别名:
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2; KIAA0733; MAP3K7IP2; TAB2
形态:
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
保存条件:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.