TAB2 抗体-TAB2 Antibody

TAB2 抗体，TAB2 Antibody，TAB2 抗体,TAB2 Antibody

产品名称：TAB2 抗体-TAB2 Antibody

产品货号：PSI-3389-0.02mg

产品规格：0.02mg

背景资料：TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

保存建议：TAB2 抗体-TAB2 Antibody stored at 4℃ for three months and -20℃, stable for up to one year

应用类型：E, IHC-P

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