- ￥3000 - 3999
- Abbiotec
- 美国
- 252575
- 2025年07月08日
- E, WB, IHC
- Mouse
- H
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser190 of human progesterone receptor.
- 亚型：
Mouse IgG1
- 形态：
Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
- 保存条件：
Store at -20°C.
- 克隆性：
单克隆
- 标记物：
见下方详细说明
- 适应物种：
H
- 保质期：
1-2年
- 抗原来源：
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser190 of human progesterone receptor.
- 目录编号：
252575
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Mouse
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
Progesterone Receptor (Ser190)
- 抗体英文名：
Progesterone Receptor (Ser190) Antibody
- 抗体名：
Progesterone Receptor (Ser190) Antibody
- 规格：
0.1 ml
Progesterone Receptor (Ser190) Antibody产品详细介绍：
| 产品名称： | Progesterone Receptor (Ser190) Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 252575 |
| 规格： | 0.1 ml |
| 产品描述： | There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor. |
| 克隆类型： | Mouse Monoclonal Antibody, Phosphospecific Antibody |
| 亚型： | Mouse IgG1 |
| 免疫原： | KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser190 of human progesterone receptor. |
| 适用物种： | H |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:1,000; IHC: 1:1,000; WB: 1:1,000 |
| 别名： | Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3 |
| 形态： | Each vial contains 0.1 ml IgG in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography. |
| 保存条件： | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献： |
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文献和实验Human progesterone receptor (PR) is a member of the nuclear hormone receptor superfamily of transcriptional activators, which share a common modular structure consisting of a C-terminal ligand-binding domain (LBD), a highly conserved
Several assays exist to determine receptor status in ovarian cancers, like radio ligand binding assays, biochemical analysis, and even Northern blotting. However, patholo- gists generally prefer to judge the presence of biological markers
Steroid hormones, such as estrogen, progesterone, androgens, glucocorticoids, and mineralocorticoids, are well-known regulators of the expression of specific gene networks in higher eukaryotes (1 –3 ). The hormonal action is mediated
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