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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser80 of human MeCP2.
- 亚型:
Rabbit Ig
- 形态:
Each vial contains 0.1 ml crude serum in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography.
- 保存条件:
Store at -20°C.
- 克隆性:
多克隆
- 标记物:
见下方详细说明
- 适应物种:
H, M, R
- 保质期:
1-2年
- 抗原来源:
KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser80 of human MeCP2.
- 目录编号:
252553
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Rabbit
- 应用范围:
E, WB, IHC
- 浓度:
见详细说明信息
- 靶点:
MeCP2 (Ser80)
- 抗体英文名:
MeCP2 (Ser80) Antibody
- 抗体名:
MeCP2 (Ser80) Antibody
- 规格:
0.1 ml
MeCP2 (Ser80) Antibody产品详细介绍:
| 产品名称: | MeCP2 (Ser80) Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 252553 |
| 规格: | 0.1 ml |
| 产品描述: | Methyl-CpG-binding protein 2 (MeCP2) is a chromosomal protein that binds to methylated DNA. MeCP2 can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. MeCP2 mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Defects in MeCP2 are linked to Angelman syndrome (AS), also known as happy puppet syndrome. AS is a neurodevelopmental disorder characterized by severe mental retardation, absent speech, ataxia, sociable affect and dysmorphic facial features. AS and Rett syndrome have overlapping clinical features. Phosphorylation and dephosphorylation of Ser80 is involved in modulating the dynamic function of MECP2 in neurons transiting between resting and active states within neural circuits that underlie behaviors. |
| 克隆类型: | Rabbit Polyclonal Antibody, Phosphospecific Antibody |
| 亚型: | Rabbit Ig |
| 免疫原: | KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser80 of human MeCP2. |
| 适用物种: | H, M, R |
| 应用范围: | E, WB, IHC |
| 应用说明: | E: 1:1,000; WB: 1:1,000 IHC 1:100 |
| 别名: | Methyl-CpG-binding protein 2; MeCp-2 protein; MeCp2; MECP2 |
| 形态: | Each vial contains 0.1 ml crude serum in HEPES pH7.5, 150 mM NaCl, 0.01% BSA and 50% glycerol. Antibody was purified by immunogen affinity chromatography. |
| 保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 参考文献: |
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