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- MultiSciences
- 15.63 pg/mL - 1000 pg/mL
- 杭州
- EK213
- 2025年12月17日
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- 技术资料
- 库存：
99
- 供应商：
联科生物
- 检测范围：
15.63 pg/mL - 1000 pg/mL
- 检测方法：
双抗夹心法
- 应用：
ELISA
- 适应物种：
Mouse
- 标记物：
HRP
- 样本：
血清，血浆，细胞培养上清及其他生物学样本
- 规格：
96T/48T
| 规格： | 96T | 产品价格： | ￥2650.0 |
|---|---|---|---|
| 规格： | 48T | 产品价格： | ￥1600.0 |
| 背景介绍 | 白细胞介素13(IL-13)位于染色体5q31上，与IL-4具有30%的同源性和相似的结构。IL-13由许多细胞类型分泌产生，尤其是2型辅助性T细胞(Th2)。与密切相关的IL-4相似，IL-13对免疫细胞也具有多种功能。虽然IL-13主要与气道疾病的诱导相关，但是它还具有消炎特性。IL-13可诱导造血细胞的变化，但是这些效果与IL-4相比可能不那么重要。
IL-13专门诱导寄生感染的器官的生理变化。它也可诱导过敏性肺部疾病的许多特征，包括气道高反应性、杯状细胞增殖和黏液高分泌，这些都会导致气道阻塞。此外，IL-13抑制原代培养衍生的巨噬细胞中HIV-1的复制，可作为体内单核细胞和巨噬细胞中抑制HIV感染的候选细胞因子。 |
| 检测原理 | 本试剂盒采用双抗体夹心酶联免疫吸附检测技术。特异性抗小鼠IL-13抗体预包被在高亲和力的酶标板上。酶标板孔中加入标准品、待测样本和生物素化的检测抗体，经过孵育，样本中存在的IL-13与固相抗体和检测抗体结合。洗涤去除未结合的物质后，加入辣根过氧化物酶标记的链霉亲和素(Streptavidin-HRP)。洗涤后，加入显色底物TMB，避光显色。颜色反应的深浅与样本中IL-13的浓度成正比。加入终止液终止反应，在450 nm波长(参考波长570 - 630 nm)测定吸光度值。 |
| 组分 | 包被抗IL-13单克隆抗体的96孔聚苯乙烯酶标板 小鼠IL-13冻干标准品 IL-13检测抗体 标准品稀释液 检测缓冲液(10×) 底物(TMB) 终止液 洗液(20×) 封板膜 |
| 分析类型 | 夹心ELISA |
| 样本类型 | 血清、血浆，细胞培养上清及其他生物学样本 |
| 板式 | 96孔板，可拆 |
| 保存 | 试剂盒未拆开，4℃保存。已拆开，标准品-20℃保存，其它4℃保存。 |
| 运输条件 | 4℃蓝冰运输 |
| 样本体积 | 20 μl |
| 灵敏度 | 1.17 pg/ml |
| 标曲图 |  |
| 标准曲线范围 | 15.63 - 1000 pg/ml |
| 回收率范围 | 89 %-112 % |
| 平均回收率 | 1.02 |
| 板间变异系数 | 2.3 % - 3.0 % |
| 板内变异系数 | 2.1 % - 5.3 % |
IL13 分子靶点信息概述
- 分子名：IL13, interleukin 13
- 基因家族：Interleukins
- 别名：P600; IL-13; ALRH; BHR1; MGC116786; MGC116788; MGC116789
- 全称：allergic rhinitis; Bronchial hyperresponsiveness-1 (bronchial asthma)
IL13 分子靶点综述
白细胞介素13(IL-13)位于染色体5q31上，与IL-4具有30%的同源性和相似的结构。IL-13由许多细胞类型分泌产生，尤其是2型辅助性T细胞(Th2)。与密切相关的IL-4相似，IL-13对免疫细胞也具有多种功能。虽然IL-13主要与气道疾病的诱导相关，但是它还具有消炎特性。IL-13可诱导造血细胞的变化，但是这些效果与IL-4相比可能不那么重要。IL-13专门诱导寄生感染的器官的生理变化。它也可诱导过敏性肺部疾病的许多特征，包括气道高反应性、杯状细胞增殖和黏液高分泌，这些都会导致气道阻塞。此外，IL-13抑制原代培养衍生的巨噬细胞中HIV-1的复制，可作为体内单核细胞和巨噬细胞中抑制HIV感染的候选细胞因子。
小鼠 Mouse Il13 分子靶点信息
- 分子名：Il13, interleukin 13
- 别称：
- Il-13
- 基因序列：NCBI_Gene: 16163
- 蛋白序列：
- UniprotKB: P20109
小鼠 Mouse Il13 靶点分子功能（预测）
Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13).
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Mouse IL-13 ELISA Kit（小鼠白介素13 ELISA试剂盒）
￥1600 - 2650
