- ￥2260
- LSM Bio
- 进口
- PAab09926
- 2025年07月17日
- ELISA, WB
- E. coli - derived recombinant protein
- Human, Mouse, Rat
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 免疫原：
Suppressor of cytokine signaling 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
Suppressor of cytokine signaling 1
- 抗体英文名：
SOCS1 antibody
- 抗体名：
SOCS1 antibody
- 规格：
100μl
SOCS1 antibody
Product Name SOCS1 antibody
Catalog No PAab09926
Packing 100ul
Form liquid
Alternative Name CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
Immunogen Suppressor of cytokine signaling 1
Specificity Human, Mouse, Rat
Tested Application ELISA, WB
Recommended dilution WB: 1:500 - 1:2000
IHC use
WB use
mouse lung were subjected to SDS PAGE followed by western blot with PAab09926 (SOCS1 antibody) at dilution of 1:1000
Protein Information
Gene ID 8651
Uniprot ID O15524
Calculated MW 24 kDa
Research Area Metabolism, Signal Transduction
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- 作者
- 内容
- 询问日期
文献和实验Detection of Endogenous SOCS1 and SOCS3 Proteins by Immunoprecipitation and Western Blot Analysis
The suppressors of cytokine signalling (SOCS) protein family consist of eight members (SOCS 1–7, and CIS). SOCS1 and SOCS3 are the best-studied family members and have been shown to act as negative feedback inhibitors of the JAK/STAT
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
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