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- 详细信息
- 文献和实验
- 技术资料
- 库存:
59
- 英文名:
Recombinant Human Receptor tyrosine-protein kinase ErbB-2
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃
- 规格:
10μg|50μg|500μg|1mg
特别提示:包括重组人HER2(ERBB2)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:重组人HER2(ERBB2)
英文名称:Recombinant Human Receptor tyrosine-protein kinase ErbB-2
产品货号:JN1886
产品规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Thr23-Thr652在C端带有Fc标签。
HER2/ERBB2质量控制:>95%(还原性SDS-PAGE)
HER2/ERBB2制剂:冻干品
HER2/ERBB2保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
HER2/ERBB2复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于HER2/ERBB2:
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5-TCAAATTC-3 sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
我公司销售的重组人HER2(ERBB2)报价,rERBB2,重组HER2,重组人ERBB2,rhHER2,Recombinant Human Receptor tyrosine-protein kinase ErbB-2,重组人HER2,重组Receptor tyrosine-protein kinase ErbB-2,重组人Receptor tyrosine-protein kinase ErbB-2,重组ERBB2,rHER2,rhERBB2质量上佳,价格普惠,欢迎广大新老客户踊跃订购。
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文献和实验Assay for Isolation of Inhibitors of Her2-Kinase Expression
Her2 (ErbB2) protein is overexpressed in breast and other solid tumors, and its expression is associated with progressive disease. Current therapies directed toward Her2 either block dimerization of the receptor or inhibit tyrosine kinase
Automated Analysis of FISH-Stained HER2/neu Samples with Metafer
The HER2/neu gene (also known as ERBB2) is located on chromosome 17 (q11.2–q12) and encodes a glycoprotein known to be a member of the epidermal growth factor receptor family. Clinically, the determination of its amplification status
Her2为啥是ErbB信号通路的关键呢?因为没有她,就没法穿搭……
ErbB信号通路,是个做妇科肿瘤常见的信号通路,特别是乳腺癌研究中,对HER2的研究都很常见。为啥HER2(也就是ErbB2)的研究会这么多,这和ErbB信号通路本身是分不开的。我们先来看看ErbB信号通路是什么鬼?嗯,这个复杂程度,就有点令人发指了,不光是进入细胞后的内容丰富,膜受体也是特别复杂。夏老师给你们稍微简化一下,差不多就是这样:还是有点复杂,不是么?实际上,造成ErbB信号通路这么复杂的原因,主要就是ErbB信号通路的膜受体,一共有这么四种:ErbB1(也就是EGFR),ErbB2
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