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Recombinant Human IGF-I,重组人IGF

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  • 询价
  • wksubio
  • YJ100-11
  • Peprotech
  • 2026年05月29日
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    上海瓦兰生物科技有限公司
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    • 技术资料
    • 英文名：

      Recombinant Human IGF-I

    • 保质期：

      2年

    • 供应商：

      上海瓦兰生物

    • 保存条件：

      -20°

    • 库存：

      大量

    • 规格：

      10µg

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    Recombinant Human IGF-I

    产品编号:
    100-11
    别名:
    Insulin-like Growth Factor-I,Somatamedin C,IGF-IA
    描述:
    The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.
    氨基酸序列:
    GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA
    来源:
    E.coli
    纯度:
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    生物活性:
    The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
    交叉反应:
    Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander

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