Guggulsterone香胶甾酮,95975-55-6

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Guggulsterone

CAS No. : 95975-55-6

MCE 国际站：Guggulsterone

产品活性：Guggulsterone 是一种植物甾醇，来自 Commiphora wightii 树的树胶脂。 Guggulsterone 通过下调抗细胞凋亡 (apoptosis) 基因产物 (IAP1，xIAP，Bfl-1/A1，Bcl-2，cFLIP，survivin)，调节细胞周期蛋白 (cyclin D1，c-Myc)，激活 caspases，JNK，抑制 Akt，抑制多种肿瘤细胞的生长并诱导细胞凋亡。Guggulsterone 通过调节几种转录因子介导基因表达，包括 NF-κB，STAT3，C /EBPα，雄激素受体 (androgen receptor) 和糖皮质激素受体(glucocorticoid receptors)。Guggulsterone，一种法尼醇 X 受体 (FXR) 拮抗剂，可降低 CDCA 诱导的 FXR 活化，Z- 和 E-Guggulsterone 的 IC₅₀ 分别为 17 和 15 μM。

研究领域：Apoptosis  |  MAPK/ERK Pathway  |  PI3K/Akt/mTOR  |  Metabolic Enzyme/Protease  |  Autophagy

作用靶点：Apoptosis  |  JNK  |  Akt  |  Caspase  |  FXR  |  Autophagy

In Vitro: Guggulsterone (0.5-20 μM; 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS.

In Vivo: Guggulsterone (orally; 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis.

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