Tonapofylline,340021-17-2

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Tonapofylline

CAS No. : 340021-17-2

MCE 国际站：Tonapofylline

产品活性：Tonapofylline (BG 9928) 是一种具有口服活性和选择性 A₁ 腺苷受体拮抗剂，对人 A₁ 腺苷受体 (hA₁) 的 K_i 为 7.4 nM，选择性高出 A_2A 腺苷受体 915 倍，A_2B 腺苷受体 12 倍，有用于研究心力衰竭的潜力。

研究领域：GPCR/G Protein

作用靶点：Adenosine Receptor

In Vivo: Tonapofylline (BG 9928) (1 mg/kg; p.o., b.i.d, days 0-6) produces sustained reductions in post-NSC 119875 serum creatinine and blood urea nitrogen levels, improves body weight recovery and significant attenuation of NSC 119875-induced (5.5 mg/kg) kidney pathology scores.

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