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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
913822-46-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1053.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥377.0 |
| 规格： | 5 mg | 产品价格： | ￥846.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2400.0 |
| 规格： | 50 mg | 产品价格： | ￥3840.0 |
| 规格： | 100 mg | 产品价格： | ￥5760.0 |
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SC75741
CAS No. : 913822-46-5
MCE 国际站：SC75741
产品活性：SC75741 是一种广泛，有效的 NF-κB 抑制剂，对 p65 的 IC50 为 200 nM。SC75741 可阻断 influenza viruses 复制。SC75741 通过损害 NF-κB 亚基 p65 的 DNA 结合，导致细胞因子，趋化因子和促凋亡因子的表达降低，抑制 caspase 活化和阻断 caspase 介导的病毒核糖核蛋白 (viralribonucleoproteins) 的核输出。
研究领域：NF-κB | Anti-infection
作用靶点：NF-κB | Influenza Virus
In Vitro: SC75741 (5 μM; 24-96 hours) inhibits long-term A549 cells proliferation.
SC75741 (1-10 μM; 5.5-65 hours) reduces A549 cells viability in a concentration-dependent manner indicating a cytostatic effect for A549 cells within a time frame of about 50 and 65 hours.
SC75741 (5 μM; 24 hours) strongly inhibits cleavage of the effector caspase 3 induced upon H7N7-infection.
In Vivo: SC75741 (intraperitoneal injection; 15 mg/kg; for 2 days) leads to a reduced propagation of the H5N1 virus mRNA by 90% in the lungs of infected mice.
The plasma-levels of SC74751 (intravenously of 5 mg/kg and intraperitoneally of 15 mg/kg; for 3.5 and 6 hours) after i.v. administration decreases mono-exponentially and half-life is roughly 40 min. After i.p. administration, elimination of SC75741 seems to be limited by a slow uptake from the peritoneum and a half-life of 55 min is observed.
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文献和实验Signal Transduction Inhibitors in Cellular Function
CAAX peptide analogues BZA-5B, L-739, Cys-4-ABA-Met FT1-276, SCH44342, SCH66336 (57 –59) Bisubstrate inhibitors
mg/L尿液样品，在1 d内按样品测定法重复测定6次，求得日内RSD分别为1.46%, 1.09%和0.48%. 将上述3个浓度的样品在3 d内连续各重复测定6次，求得日间RSD分别为1.63%, 1.37%和1.06%. 2.5样品稳定性试验 2.5.1头孢噻肟血浆和尿液样品-20℃放置稳定性试验将低、中、高（10.6, 106和424 mg/L）3个浓度的头孢噻肟血浆样品和尿液样品分别置于-20℃冰箱内1, 2, 3 d；另将低、中、高（10.9, 109和436 mg
were significantly decreased. High expressions of Bcl-2 and Bax were detected in 1 and 2μmol/L arseni c trioxide-treated cells, these were 46%, 87.33% and 83.08%, 95.83% respecti vely, among which that of Bax was more significant. Arsenic trioxide treatment at 0.5μ
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