HSPA1A| Human Heat shock 70 kD

Preparation of a Heat-Shock Protein 70-Based Vaccine from DCTumor Fusion Cells

We have developed an enhanced molecular chaperone-based vaccine through rapid isolation of heat-shock protein 70 peptide complexes (Hsp70.PC) after the fusion of tumor and dendritic cells (DCs) (Hsp70.PC-F). In this approach, the tumor

热休克蛋白 heat-shock protein

指将生物的整体、组织、细胞等从其生活的温度范围内急剧地从低温移向高温时，可显著地促进合成的一组蛋白质。例如将果蝇的幼虫或培养细胞从28℃移至 35℃时，则几乎大部分的蛋白质合成停止；与此相反，而休克蛋白的合成却反而被促进。这种促进作用主要是在转录 DNA的合成（转录）阶段产生的。同样的现象也见于哺乳类动物、培养细胞、原生动物、植物组织和细菌等。另外观察到，由休克以外的其他处理也会发生类似的现象。这种现象的生理意义尚不清楚，但推测是与生物的温度适应现象有关系。  

Stress Response Profiles in Human Fibroblasts Exposed to Heat Shock or Oxidative Stress

demonstrated a specific upregulation of Hsp70 mRNA and protein after heat shock, while heme oxygenase 1 (HO1 or Hsp32) mRNA and protein was specifically upregulated following H2 O2 -induced oxidative stress. Hsp70 and HO1 should therefore be considered