- ￥2260
- LSM Bio
- 进口
- PAab09571
- 2025年07月10日
- ELISA,WB
- E. coli - derived recombinant protein
- Human,Mouse ,Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
YTH domain containing 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human,Mouse ,Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
O95498
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
YTH domain containing 1
- 抗体英文名：
anti-YTHDC1 antibody,YTHDC1 antibody
- 抗体名：
anti-YTHDC1 抗体,YTHDC1 抗体
- 规格：
100μl
YTHDC1抗体| YTHDC1 antibody
货号 PAab09571
蛋白别名 KIAA1966 antibody, Putative splicing factor YT521 antibody, YT521 antibody, YT521 B antibody, YTH domain containing 1 antibody, YTHDC1
蛋白介绍
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A- containing mRNAs and promotes recruitment of SRSF3 to its mRNA- binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602).
产品描述
anti-YTHDC1 antibody is a Rabbit Polyclonal antibody againstYTHDC1..
建议稀释比例
WB : 1:200-1:1000
IHC
Western blot
MCF-7 cells were subjected to SDS PAGE followed by western blot with PAab09571( YTHDC1 Antibody) at dilution of 1:300(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验
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