- ￥2860
- LSM Bio
- 进口
- PAab09121
- 2025年07月08日
- ELISA,IHC,IF
- E. coli - derived recombinant protein
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
TXK tyrosine kinase
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,IHC,IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
TXK tyrosine kinase
- 抗体英文名：
anti-TXK antibody,TXK antibody
- 抗体名：
anti-TXK 抗体,TXK 抗体
- 规格：
100μl
TXK抗体| TXK antibody
货号 PAab09121
蛋白别名 TXK antibody, Protein tyrosine kinase 4 antibody, TXK tyrosine kinase antibody, TKL antibody, BTKL
蛋白介绍
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
产品描述
anti-TXK antibody is a Rabbit Polyclonal antibody againstTXK..
建议稀释比例
IF:1:10-1:100;IHC:1:20-1:200
IHC
Immunohistochemical of paraffin-embedded human lymphoma using PAab09121(TXK antibody) at dilution of 1:100
Western blot
(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验12, TCF3, TCF7, TCF7L1, TCF7L2, TCF8, TGFB2, TGFBR3, TIAL1, TLX1, TM4SF2, TNFRSF17, TNFRSF8, TNK1, TOP1, TXK, TYMS, VAV2, VHL, WEE1, WT1, YWHAQ, ZAP70, ZNF145, ZNF42, ZNF593, ZNFN1A1. 请勿重复发贴！
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