- ￥2260
- LSM Bio
- 进口
- PAab09019
- 2025年07月16日
- ELISA,WB,IHC
- E. coli - derived recombinant protein
- Human, Mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
transient receptor potential cation channel, subfamily C, member 6
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
Polyclonal antibody
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA,WB,IHC
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
transient receptor potential cation channel, subfamily C, member 6
- 抗体英文名：
anti-TRPC6 antibody,TRPC6 antibody
- 抗体名：
anti-TRPC6 抗体,TRPC6 抗体
- 规格：
100μl
TRPC6抗体| TRPC6 antibody
货号 PAab09019
蛋白别名 FLJ11098 antibody, FLJ14863 antibody, FSGS2 antibody, Transient receptor protein 6 antibody, TRP 6 antibody, TRP6 antibody, TRPC6
蛋白介绍
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
产品描述
anti-TRPC6 antibody is a Rabbit Polyclonal antibody againstTRPC6..
建议稀释比例
WB:N/A;IP:1:200-1:1000;IHC:1:20-1:200
IHC
Immunohistochemistry of paraffin-embedded human placenta tissue slide using PAab09019( TRPC6 Antibody) at dilution of 1:50
Western blot
mouse brain tissue were subjected to SDS PAGE followed by western blot with PAab09019(TRPC6 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!) "">
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文献和实验Neuron：北大陈雷研究组报道胞内钙离子对 TRPC3/6 通道调控的机制
经典型瞬时受体电势通道 TRPC 是一类通透钙离子的非选择性阳离子通道1，与最早在果蝇感光系统中发现的 TRP 通道的序列相似性最高2,3，并且可以被第二信使 DAG 所激活。根据序列相似性以及通道的电生理特性，TRPC3/6/7 形成了一个亚类4。 TRPC3/6/7 通道参与多种神经活动，例如 TRPC3 在中枢神经系统高表达，参与神经生长因子 BDNF 信号转导5，同时 TRPC3 还与神经突触信号传递以及运动协调有关6,7。TRPC6 通道可以促进神经元存活以及兴奋性突触的形成
Single-Channel Analysis of TRPC Channels in the Podocytes of Freshly Isolated Glomeruli
basement membrane turnover. Dysfunction of podocytes is a major cause of glomerular kidney diseases. Gain-of-function mutations in the TRPC6 channel underlie a subset of familial forms of focal segmental glomerulosclerosis (FSGS). While growing evidence
Measurement and Manipulation of Intracellular Ca2+ in Single Platelets and Megakaryocytes
-dependent Ca2+ influx also seems to exist in the platelet (9 ) and TRPC6, a nonselective cation channel known to be activated by the PLC product diacylglycerol (DAG), has recently been detected in platelets and megakaryocytic cell lines (10 ). Finally
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