TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).
产品描述
anti-TGF-beta 1 antibody is a Rabbit Polyclonal antibody againstTGF-beta 1..
建议稀释比例
WB:1:200-1:2000;IHC:1:50-1:500
IHC
Immunohistochemistry of paraffin-embedded human breast cancer tissue slide usingPAab08638( TGFB1 Antibody) at dilution of 1:200
Western blot
MCF-7 cells were subjected to SDS PAGE followed by western blot with PAab08638( TGFB1 Antibody) at dilution of 1:600(本抗体仅供体外科研用途,不可用于临床诊断!)