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Recombinant Human BMP-2 重组人骨形态

发生蛋白
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  • ¥1140
  • Peprotech
  • 120-02
  • Peprotech
  • 2026年01月30日
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    • 详细信息
    • 询价记录
    • 文献和实验
    • 技术资料
    • 英文名

      Recombinant Human BMP-2

    • 保质期

      2年

    • 供应商

      上海瓦兰生物

    • 保存条件

      -20°

    • 库存

      大量

    • 规格

      2µg

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    别名:
    BMP-2A
    描述:
    BMPs (Bone Morphogenetic Proteins) belong to the TGF-β superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
    氨基酸序列:
    MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
    来源:
    E.coli
    纯度:
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    生物活性:
    Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
    交叉反应:
    Cow, Dog, Monkey, Mouse, Rabbit, Rat

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