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- H9633-250mg
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
50⁺瓶
- 英文名：
L-2-AMINO-4-SULFOBUTYRIC ACID
- CAS号：
14857-77-3
- 保质期：
1年
- 供应商：
上海睿安生物19121878899
- 保存条件：
Room Temperature
- 规格：
250mg/瓶
Sigma货号H9633-25mg现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
Sigma货号H9633-250mg现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
Sigma货号H9633-1g现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
L-同型半胱氨酸
≥98%(TLC)
别名:L-2-氨基-4-磺基丁酸
经验公式(希尔记法):C4H9NO5S
化学文摘社编号:14857-77-3
分子量:183.18
UNSPSC Code:12352106
PubChem Substance ID:24895863
NACRES:NA.32
MDL number:MFCD00066018
属性
产品名称:L-同型半胱氨酸,≥95%
SMILES string:N[C@@H](CCS(O)(=O)=O)C(O)=O
InChI:1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
InChI key:VBOQYPQEPHKASR-VKHMYHEASA-N
assay:
≥95%
≥98%(TLC)
form:powder
color:white to off-white
application(s):cell analysis
Quality Level:200
说明
Application:L-同型半胱氨酸已被用于研究在神经系统中过氧化氢介导的生理和病理状态变化。
Biochem/physiol Actions
L-同型半胱氨酸(L-HCA)是NMDA(N-甲基-D-天冬氨酸)受体的一种内源性神经递质配体。它是谷氨酸的一种类似物，可竞争性抑制神经元中谷氨酸-半胱氨酸(xc)反转运蛋白的功能，引起半胱氨酸摄取量下降。
同行评审论文(部分:文献)
Fast photochemical oxidation of proteins (FPOP): A powerful mass spectrometry-based structural proteomics tool.
Danté T Johnson et al.
The Journal of biological chemistry, 294(32), 11969-11979 (2019-07-03)
Fast photochemical oxidation of proteins (FPOP) is a MS-based method that has proved useful in studies of protein structures, interactions, conformations, and protein folding. The success of this method relies on the irreversible labeling of solvent-exposed amino acid side chains
L-homocysteic acid but not L-glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro.
T Knöpfel et al.
Neuroscience letters, 81(1-2), 188-192 (1987-10-16)
The effects of ionophoretically applied L-homocysteate (L-HCA), L-glutamate (L-Glu) and N-methyl-D-aspartate (NMDA) were compared in rat neocortical neurons recorded intracellularly in vitro. The firing pattern and the time course of membrane depolarization induced by L-HCA resembled those of NMDA responses.
Hippocampal modulation of cardiorespiratory function.
Itopa E Ajayi et al.
Respiratory physiology & neurobiology, 252-253, 18-27 (2018-03-20)
Changes in cardiorespiratory control accompany the expression of complex emotions, indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have focussed on the role of the prefrontal cortex in autonomic regulation. However, the role of the hippocampus, also
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor.
J W Olney et al.
Brain research bulletin, 19(5), 597-602 (1987-11-01)
L-Homocysteic acid (L-HCA) has been proposed as a natural transmitter at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor based on recent evidence that L-HCA occurs L-HCA occurs naturally in the mammalian CNS, is released from K+ stimulated brain
A validated LC-MS/MS method for the determination of homocysteic acid in biological samples.
R Gurke et al.
Journal of pharmaceutical and biomedical analysis, 174, 578-587 (2019-07-02)
The role of homocysteic acid (HCA) in severe diseases like Alzheimer's disease is under discussion and some recent studies correlate elevated HCA concentrations with the diagnosis of Alzheimer's. However, non-selective and insufficiently sensitive methods have been used to quantitate HCA
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文献和实验该产品被引用文献
Sigma货号H9633-25mg现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
Sigma货号H9633-250mg现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
Sigma货号H9633-1g现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
L-同型半胱氨酸
≥98%(TLC)
别名:L-2-氨基-4-磺基丁酸
经验公式(希尔记法):C4H9NO5S
化学文摘社编号:14857-77-3
分子量:183.18
UNSPSC Code:12352106
PubChem Substance ID:24895863
NACRES:NA.32
MDL number:MFCD00066018
属性
产品名称:L-同型半胱氨酸,≥95%
SMILES string:N[C@@H](CCS(O)(=O)=O)C(O)=O
InChI:1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1
InChI key:VBOQYPQEPHKASR-VKHMYHEASA-N
assay:
≥95%
≥98%(TLC)
form:powder
color:white to off-white
application(s):cell analysis
Quality Level:200
说明
Application:L-同型半胱氨酸已被用于研究在神经系统中过氧化氢介导的生理和病理状态变化。
Biochem/physiol Actions
L-同型半胱氨酸(L-HCA)是NMDA(N-甲基-D-天冬氨酸)受体的一种内源性神经递质配体。它是谷氨酸的一种类似物，可竞争性抑制神经元中谷氨酸-半胱氨酸(xc)反转运蛋白的功能，引起半胱氨酸摄取量下降。
同行评审论文(部分:文献)
Fast photochemical oxidation of proteins (FPOP): A powerful mass spectrometry-based structural proteomics tool.
Danté T Johnson et al.
The Journal of biological chemistry, 294(32), 11969-11979 (2019-07-03)
Fast photochemical oxidation of proteins (FPOP) is a MS-based method that has proved useful in studies of protein structures, interactions, conformations, and protein folding. The success of this method relies on the irreversible labeling of solvent-exposed amino acid side chains
L-homocysteic acid but not L-glutamate is an endogenous N-methyl-D-aspartic acid receptor preferring agonist in rat neocortical neurons in vitro.
T Knöpfel et al.
Neuroscience letters, 81(1-2), 188-192 (1987-10-16)
The effects of ionophoretically applied L-homocysteate (L-HCA), L-glutamate (L-Glu) and N-methyl-D-aspartate (NMDA) were compared in rat neocortical neurons recorded intracellularly in vitro. The firing pattern and the time course of membrane depolarization induced by L-HCA resembled those of NMDA responses.
Hippocampal modulation of cardiorespiratory function.
Itopa E Ajayi et al.
Respiratory physiology & neurobiology, 252-253, 18-27 (2018-03-20)
Changes in cardiorespiratory control accompany the expression of complex emotions, indicative of limbic brain inputs onto bulbar autonomic pathways. Previous studies have focussed on the role of the prefrontal cortex in autonomic regulation. However, the role of the hippocampus, also
L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor.
J W Olney et al.
Brain research bulletin, 19(5), 597-602 (1987-11-01)
L-Homocysteic acid (L-HCA) has been proposed as a natural transmitter at the N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor based on recent evidence that L-HCA occurs L-HCA occurs naturally in the mammalian CNS, is released from K+ stimulated brain
A validated LC-MS/MS method for the determination of homocysteic acid in biological samples.
R Gurke et al.
Journal of pharmaceutical and biomedical analysis, 174, 578-587 (2019-07-02)
The role of homocysteic acid (HCA) in severe diseases like Alzheimer's disease is under discussion and some recent studies correlate elevated HCA concentrations with the diagnosis of Alzheimer's. However, non-selective and insufficiently sensitive methods have been used to quantitate HCA
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Sigma货号H9633-250mg现货L-同型半胱氨酸19121878899上海睿安生物Sigma官方正式授权代理商
￥3828.37
