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- 详细信息
- 技术资料
- 生长状态：
悬浮生长
- ATCC Number：
HB-240™
- 库存：
大量
- 免疫类型：
IgG2a
- 细胞形态：
淋巴样
- 物种来源：
大鼠
- 是否是肿瘤细胞：
0
- 运输方式：
冻存运输
| Designations: | 4D11 | ||
| Depositors: | LH Mason | ||
| Isotype: | IgG2a | ||
| Biosafety Level: | 1 | ||
| Shipped: | frozen | ||
| Medium & Serum: | See Propagation | ||
| Growth Properties: | suspension | ||
| Organism: | Rattus norvegicus (B cell); Mus musculus (myeloma) deposited as rat (B cell); mouse (myeloma) | ||
| Morphology: | lymphoblast |
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| Source: | Cell Type: hybridoma: B lymphocyte; | ||
| Cellular Products: | immunoglobulin; monoclonal antibody; against an antigen on mouse NK cells (LGL-1) | ||
| Permits/Forms: | In addition to the MTA mentioned above, other ATCC and/or regulatory permits may be required for the transfer of this ATCC material. Anyone purchasing ATCC material is ultimately responsible for obtaining the permits. Please click here for information regarding the specific requirements for shipment to your location. | ||
| Comments: | Animals were immunized with C57BL/6 mouse liver derived large granular lymphocytes in the presence of rat antiserum against NK cell depleted C57BL/6 mouse spleen cells. Spleen cells were fused with NS-1 myeloma cells. The antibody detects a major (approximately 50%) subset of mouse NK cells. This subset (LGL-1+/NK-1.1+) functions in NK type lysis, but lacks LAK (lymphokine activated killing) activity against P815 and L5178Y tumor target cells. The antigen recognized by 4D11 appears to be nonpolymorphic, and is present in all mouse strains tested. |
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| Propagation: | ATCC complete growth medium: RPMI 1640 medium with 0.05 mM 2-mercaptoethanol, 90%; fetal bovine serum, 10% |
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| Subculturing: | Medium Renewal: Every 2 to 3 days Cultures can be maintained by addition or replacement of fresh medium. Start cultures at 2 X 10 exp5 cells/ml and maintain between 1 X 10 exp5 and 1 X 10 exp6 cells/ml. |
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| References: | 22841: Mason LH, et al. Natural killer (NK) cell subsets in the mouse. NK-1.1+/LGL-1+ cells restricted to lysing NK targets, whereas NK-1.1+/LGL-1- cells generate lymphokine-activated killer cells. J. Immunol. 145: 751-759, 1990. PubMed: 2365999 23471: Mason L, et al. LGL-1: a non-polymorphic antigen expressed on a major population of mouse natural killer cells. J. Immunol. 140: 4403-4412, 1988. PubMed: 2453582 |
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4D11
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