- ¥380 - 3800
- 百奥莱博
- L10429-HCV
- 北京
- 2025年07月15日
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- 详细信息
- 技术资料
- 库存：
263
- 英文名：
Agomelatine
- CAS号：
138112-76-2
- 保质期：
长期
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
2-8℃
- 规格：
5mg|50mg|25mg|250mg|1g|5g|25g
特别提示：包括阿戈美拉汀在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：阿戈美拉汀
英文名称：Agomelatine
产品货号：L10429
产品规格：5mg|50mg|25mg|250mg|1g|5g|25g
属性
| CAS号 | 138112-76-2 |
| 分子式 | C15H17NO2 |
| 分子量 | 243.30 |
| 存贮条件 | 储存温度2-8℃ |
描述
| 产品介绍 | Agomelatine is an extremely potent agonist at both melatonin receptors(MT1 and MT2),with additional antagonism at 5HT2C.It is a novel antidepressant with many desired in vivo properties,including neuroprotection and neurogenesis in depression-sensitive brain areas.Agomelatine′s efficacy appears to be due to both melatonergic and serotonergic properties.In neurogenesis assays,both in vitro and in vivo,the compound effects were differentially affected by antagonists for MT1/MT2 and 5HT2C,demonstrating actions through all three receptors. |
| 生化机理 | Agomelatine is a competitive antagonist of human and porcine serotonin(5-HT2C) receptors(pKi = 6.2 and 6.4,respectively) as well as human 5-HT2B receptors(pKi = 6.6).It is classified as a norepinephrine-dopamine disinhibitor(NDDI) due to its antagonism of the 5-HT2C receptor.Activation of 5-HT2C receptors by serotonin inhibits dopamine and norepinephrine release.Antagonism of 5-HT2C results in an enhancement of DA and NE release and activity of frontocortical dopaminergic and adrenergic pathways.Agomelatine is also a potent agonist at melatonin receptors which makes it the first melatonergic antidepressant.Agomelatine is an antidepressant drug. |
| 别名 | N-[2-(7-甲氧基-1-萘基)乙基]乙酰胺;S-20098;N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide |
我公司销售的阿戈美拉汀(138112-76-2)(≥98%(HPLC))，S-20098，N-[2-(7-甲氧基-1-萘基)乙基]乙酰胺，N-[2-(7-Methoxy-1-naphthalenyl)ethyl]-acetamide质量上佳，价格普惠，欢迎广大新老客户踊跃订购。
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