GeA-69,2143475-98-1

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GeA-69

CAS No. : 2143475-98-1

MCE 国际站：GeA-69

产品活性：GeA-69 是一种选择性的 PARP14 变构抑制剂，靶向作用于 macrodomain 2 (MD2)，K_d 值为 2.1 µM。GeA-69 参与 DNA 损伤修复机制，能够防止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。

研究领域：Cell Cycle/DNA Damage  |  Epigenetics

作用靶点：PARP

In Vitro: GeA-69 (compound 1) (50 μM and 250 μM; pre-damage for 1 h or 0.5, 1, 2.5 min) engages PARP14 MD2 in intact cells and prevents its localisation to sites of DNA damage in U-2 OS cells.
GeA-69 (25 nM-250 μM; 72 h) exhibits moderate cytotoxicity among HeLa, U-2 OS and HEK293 cells and highly cell permeable with 2 % passing paracellular and 98 % transcellular over the membrane.

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