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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
IPD 1151T
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
94055-76-2
- 规格：
10 mM * 1 mL/50 mg/100 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥484.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥440.0 |
| 规格： | 100 mg | 产品价格： | ￥700.0 |
| 规格： | 500 mg | 产品价格： | ￥2100.0 |
| 规格： | 1 g | 产品价格： | ￥2940.0 |
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Suplatast (Tosilate)
CAS No. : 94055-76-2
MCE 国际站：Suplatast (Tosilate)
产品活性：Suplatast Tosilate (IPD 1151T) 是一种具有口服活性的 Th2 细胞因子 (Th2 cytokine) 抑制剂，可抑制 Th2 细胞产生 IL-4 和 IL-5 ，并抑制 IgE 合成。Suplatast Tosilate 是一种抗过敏剂。Suplatast Tosilate 具有抗哮喘，抗炎和抗纤维化的作用。
作用靶点：Interleukin Related
In Vitro: IPD-1151T (1-10 μM; 10 d) induces a concentration-dependent suppression of purified allergen (Cry j 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis.
IPD-1151T (1-10 μM; 24 h) clearly depresses phytohemagglutinin (PHA)-induced expression of IL-4 mRNA in normal peripheral blood mononuclear cells (PBMC).
In Vivo: Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma.
Suplatast Tosilate (100 μg/kg; once daily for 14 d) strongly suppresses immunoglobulin E contents in serum.
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