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- 百奥莱博
- GS4914-LWV
- 北京
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
303
- 英文名：
Recombinant Human Proinsulin C-Peptide Analogue (rHuProinsulin C-Peptide Analogue)
- 保质期：
长期
- 供应商：
北京百奥莱博科技有限公司
- 保存条件：
冷冻(-20℃)
- 规格：
50μg
特别提示：包括重组人Proinsulin C-Peptide Analogue在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！
产品名称：重组人Proinsulin C-Peptide Analogue
英文名称：Recombinant Human Proinsulin C-Peptide Analogue (rHuProinsulin C-Peptide Analogue)
产品货号：GS4914
产品规格：50μg
分子量：Approximately 3.6kDa,a single non-glycosylated polypeptide chain containing 35 amino acids.
储存条件：冷冻（-20℃）
概述
Proinsulin,a molecular weight of 8 kDa to 10 kDa,is a precursor of insulin.It has minimum hormonal activity and is converted to insulin by removal of the connecting C-peptide.Mature insulin has 35 fewer amino acids;4 are removed altogether and the remaining 31 form the C-peptide.The C-peptide is abstracted from the center of the proinsulin sequence;the two other ends(the B chain and A chain)remain connected by disulfide bonds.Insulin decreases blood glucose concentration.It increases cell permeability to monosaccharides,amino acids and fatty acids.It accelerates glycolysis,the pentose phosphate cycle and glycogen synthesis in liver.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 成分 | Lyophilized from a 0.2μmfiltered solution in PBS,pH 7.4. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 内毒素 | Less than 0.1 EU/μg of rHuProinsulin C-Peptide Analogue as determined by LAL method. |
| 氨基酸序列 | RREAEDLQVG QVELGGGPGA GSLQPLALEG SLQKR |
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文献和实验为连接肽（ conneting peptide）之简写。系从胰岛素原（ proinsulin）产生胰岛素时所形成的多肽。
On the Discovery of Precursor Processing
of 30–35 amino acids and terminated with the A chain. Paired basic residues were identified at the sites of excision of the C-peptide. Human proinsulin and C-peptide were then similarly obtained and sequenced. The human C-peptide assay was developed
Assessment of Insulin Secretion in the Mouse
, proinsulin. Insulin and C-peptide are produced when endopeptidases, prohormone convertases 2 and 3 (PC2 and PC3, respectively), cleave proinsulin at two paired basic amino acid sites, Lys 64 -Arg 65 and Arg 31 -Arg 32 (
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