重组人SDF-1γ/CXCL12γ北京品牌

特别提示：包括重组人SDF-1γ/CXCL12γ在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人SDF-1γ/CXCL12γ
英文名称：Recombinant Human Stromal-Cell Derived Factor-1 gamma/CXCL12γ (rHuSDF-1γ/CXCL12γ)
产品货号：GS4917
产品规格：2μg

分子量：Approximately 11.6kDa,a single nonglycosylated polypeptide chain containing 99 amino acid residues.
储存条件：冷冻（-20℃）

概述

CXCL12 also known as SDF-1 is belonging to the CXC chemokine family.It is encoded by the CXCL12 gene.In recently study,Human CXCL12 is expressed as six isoforms that differ only in the Cterminal tail.And all SDF-1 isoforms undergo proteolytic processing of the first two Nterminal amino acids.Human SDF-1γ is synthesized as a 119 amino acid(a.a.)precursor that contains a 21 a.a.signal sequence and a 98 a.a.mature region and the SDF-1γ Cterminus binds heparin in secreted SDF-1γ,or targets the isoform to the nucleolus in the absence of a signal sequence.On the cell surface,the receptor for this chemokine is CXCR4 and syndecan4.CXCL12 is strongly chemotactic for Tlymphocytes,monocytes,but not neutrophils.CXCL12 is a very important factor in carcinogenesis and the neovascularisation linked to tumor progression.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freezedried)powder.
纯度	Sterile Filtered White lyophilized(freezedried)powder
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 30100ng/ml.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 0.1 EU/μg of rHuSDF-1γ/CXCL12γ as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKG RREEKVGKKE KIGKKKRQKK RKAAQKRKN

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