重组小鼠IL-36γ,152a.a.北京品牌

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产品名称：重组小鼠IL-36γ,152a.a.
英文名称：Recombinant Murine Interleukin-36 gamma, 152a.a. (rMuIL-36γ, 152a.a.)
产品货号：GS4912
产品规格：2μg

分子量：Approximately 17.3kDa,a single non-glycosylated polypeptide chain containing 152 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL- 1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).Furthermore,IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2.Recombinant murine IL-36γ is synthesized as a 17.3kDa,152 amino acid(a.a.)protein.Murine to human,IL-36γ shares 53%a.a.identity.Within the family,IL-36γ shares about 25%~55%a.a.sequence identity with IL-1RA,IL-1β,IL-36RA,IL-36α,IL-37,IL-36β and IL-1F10.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞98%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10ng/ml,corresponding to a specific activity of>1.0×105 IU/mg.
成分	Lyophilized froma 0.2μmfiltered concentrated solution in 20mMTris-HCl,pH 8.5,150mM NaCl with Tween-20.
内毒素	Less than 0.1 EU/μg of rMuIL-36γ,152a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	GRETPDFGEV FDLDQQVWIF RNQALVTVPR SHRVTPVSVT ILPCKYPESL EQDKGIAIYL GIQNPDKCLF CKEVNGHPTL LLKEEKILDL YHHPEPMKPF LFYHTRTGGT STFESVAFPG HYIASSKTGN PIFLTSKKGE YYNINFNLDI KS

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