重组人sTRAILR2/TNFRSF10B

特别提示：包括重组人sTRAILR2/TNFRSF10B在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人sTRAILR2/TNFRSF10B
英文名称：Recombinant Human soluble Tumor Necrosis Factor-Related Apoptosis-inducing Ligand Receptor-2
产品货号：GS4543
产品规格：10μg

分子量：Approximately 14.8kDa,a single non-glycosylated polypeptide chain containing 132 amino acids.
储存条件：冷冻（-20℃）

概述

Tumor necrosis factor-related apoptosis-inducing ligand Receptor 2(TRAIL-R2)is a cell-surface receptor involved in tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-induced cell-death signaling.The death ligand TRAIL bears high potential as a new anticancer agent,as binding to the death receptors TRAIL-R1 or TRAIL-R2 triggers apoptosis in most cancer cells.TRAIL-R2 has been shown to be associated with a decrease in the survival rates of breast cancer patients.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.rHusTRAIL-R2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC.In this assay,endogenous TRAIL is induced during a 24hourexposure to LPS(10ng/mL)but in the presence of rHusTRAIL-R2,TRAIL-induced TNF is suppressed.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHusTRAIL-R2 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	ESALITQQDL APQQRAAPQQ KRSSPSEGLC PPGHHISEDG RDCISCKYGQ DYSTHWNDLL FCLRCTRCDS GEVELSPCTT TRNTVCQCEE GTFREEDSPE MCRKCRTGCP RGMVKVGDCT PWSDIECVHK ES

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