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- 详细信息
- 文献和实验
- 技术资料
- 亚型:
Mouse IgG2b, κ
- 形态:
液体
- 保存条件:
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
- 克隆性:
Monoclonal
- 标记物:
PE/Cyanine 5.5
- 适应物种:
Human
- 保质期:
12个月
- 目录编号:
E-AB-F1212J
- 级别:
科研
- 库存:
999
- 供应商:
武汉伊莱瑞特生物科技股份有限公司
- 宿主:
Mouse
- 应用范围:
FCM
- 抗体英文名:
PerCP/Cyanine5.5 Anti-Human CD20 Antibody[2H7]_货号:E-AB-F1212J
- 抗体名:
PerCP/Cyanine5.5 Anti-Human CD20 Antibody流式抗体[2H7]_货号:E-AB-F1212J
- 规格:
100Tests/20Tests/100Tests×2
| 规格: | 100Tests | 产品价格: | ¥3168.0 |
|---|---|---|---|
| 规格: | 20Tests | 产品价格: | ¥1320.0 |
| 规格: | 100Tests×2 | 产品价格: | ¥4752.0 |

PerCP/Cyanine5.5 Anti-Human CD20 抗体流式抗体[2H7]产品名称:PerCP/Cyanine5.5 Anti-Human CD20 Antibody[2H7], 货号:E-AB-F1212J
| 产品描述: | CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82. |
| Alternate Names | Bp35;Leukocyte surface antigen Leu-16;MS4A1;B-lymphocyte surface antigen B1; |
| Swissprot | P11836 |
| Gene ID | 931 |
| Clone No | 2H7 |
| Host | Mouse |
| Reactivity | Human |
| Application | FCM |
| 同种型 | Mouse IgG2b, κ |
| 同种型 Control | PerCP/Cyanine5.5 Mouse IgG2b, κ 同种型 Control[MPC-11] |
| Conjugation | PerCP/Cyanine5.5 |
| Conjugation Information | PerCP/Cyanine5.5 is designed to be excited by the blue laser (488 nm) and detected using an optical filter centered near 675 nm (e.g., a 690/50 nm bandpass filter). |
| Spectrum | |
| 储存方法 缓冲 | Phosphate 缓冲ed solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| 储存方法 | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration date | 12个月 |
| Shipping | 冰袋 |

PerCP/Cyanine5.5 Anti-Human CD20 抗体流式抗体[2H7]labscience®拥有先进的单抗,多抗和流式抗体开发技术平台,提供8500+高品质 抗体, 适用于胞内和胞外蛋白的鉴定、定量和定位研究。抗体已在多种应用中得到验证,包含 流式细胞术(Flow Cytometry)、 免疫印迹(WB)、 免疫组化(IHC/ICC)、 免疫(共)沉淀(IP/Co-IP)、 免疫荧光(IF) 等实验。抗体产品涉及多种生命科学研究领域,包括肿瘤、免疫、心血管、细胞生物学、神经科学、表观遗传学等。Elabscience®始终致力于提高抗体的质量和种类,以保障并加快您的研究进程
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.PerCP/Cyanine5.5 Anti-Human CD20 抗体流式抗体[2H7]产品更多产品信息查看欢迎咨询我们和搜索武汉伊莱瑞特Elabscience官网查看。
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文献和实验membrane, creating a structure similar to an ion channel Delivers early signal in B cell activation, allowing resting B cells to respond to later antigens Rituximab is a chimeric murine-human anti-CD20 antibody used for treatment of B cell
因为抗体的结合而减少;在人体血清中无游离的CD20存在;最重要的是B淋巴细胞瘤上的CD20少有内吞和脱落的发生[ 2-5 ] 。1997年,以CD20为靶点的嵌合抗CD20单克隆抗体Rituxan已获准应用于B细胞淋巴瘤的治疗[ 6 ]。HI47(IgG3)是我所于1990年研制成功的国内第一个抗CD20鼠源性单克窿抗体,第四届国际人类白细胞分化抗原会议将HI47命名为CD20+X[ 7 ] 。我们利用噬菌体显示技术从HI47杂交瘤细胞中克隆到抗CD20抗体HI47可变区基因,将该基因构建成为嵌合的抗
B淋巴细胞表面的膜蛋白CD20对B淋巴细胞的增殖和分化具有调节作用[1]。由于CD20分子仅在前-B淋巴细胞、未成熟B淋巴细胞、成熟B淋巴细胞、激活B淋巴细胞中表达,而在浆细胞、淋巴多能干细胞以及其它组织均无CD20的表达[2,3,4],在人体血清中亦无游离CD20的存在[5],因此CD20可作为B淋巴细胞瘤治疗的一个理想治疗靶点。限制抗体临床使用的因素主要有抗体产生的免疫原性和抗体的生产能力是否能够满足临床需要。第四届国际人类白细胞分化抗原会议将鼠源性单克隆抗CD20抗体HI47(IgG3)正式命名为CD20+X
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