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        CD20分子

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        1631
        CD20 分子
         
        CD20
        常用单克隆抗体或代号: B1,Leu16
        主要表达细胞: B,FDC [B]
        分子质量(kDa)和结构: p33(非糖基化穿膜磷蛋白)
        功    能: Ca2+通道,调节B细胞活化和增殖
         
        CD20
        Aka L26
        33kd phosphoprotein with 3 hydrophobic regions that traverse the cell membrane, creating a structure similar to an ion channel
        Delivers early signal in B cell activation, allowing resting B cells to respond to later antigens
        Rituximab is a chimeric murine-human anti-CD20 antibody used for treatment of B cell lymphomas
        Uses: commonly used marker for B cells
        Positive staining (normal): Most B cells (after CD19 and CD10 expression, before CD21/22 expression and surface immunoglobulin expression), retained on mature B cells until plasma cell development; also follicular dendritic cells
        Positive staining (disease): 90% of B cell lymphomas, 40% of pre B ALL/LBL; 80% of lymphocyte predominant Hodgkin’s lymphoma, dimly expressed in T cells (benign and neoplastic), spindle cell thymomas
        Negative staining: non-hemaoietic cells, most T cells, plasma cells
        Micro images: large B cell lymphoma, CNS diffuse large B cell lymphoma (figure A), lymphoplasmacytic lymphoma/ Waldenström macroglobulinemia in brain-figure D
        Micro images (Mod Path subscribers): post-transplant lymphoproliferative disorder
        References: Mod Path 2002;15:647

         
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