Thevetiaflavone,29376-68-9

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Thevetiaflavone

CAS No. : 29376-68-9

MCE 国际站：Thevetiaflavone

产品活性：Thevetiaflavone 可以上调 Bcl-2 的表达，下调 Bax 和 caspase-3 的表达。

研究领域：Apoptosis

作用靶点：Bcl-2 Family  |  Caspase

In Vitro: Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca²⁺ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl-2 and downregulating that of Bax and caspase-3 in addition to increasing the activity of caspase-3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.

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