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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
GS-7340 hemifumarate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1392275-56-7
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥706.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥900.0 |
| 规格： | 25 mg | 产品价格： | ￥1438.0 |
| 规格： | 50 mg | 产品价格： | ￥2100.0 |
| 规格： | 100 mg | 产品价格： | ￥3163.0 |
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Tenofovir alafenamide hemifumarate
CAS No. : 1392275-56-7
MCE 国际站：Tenofovir alafenamide hemifumarate
产品活性：Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 Tenofovir 的前体，Tenofovir 是一种 HIV-1 核苷酸逆转录酶抑制剂。
研究领域：Anti-infection
作用靶点：HIV | Reverse Transcriptase
In Vitro: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT.
In Vivo: Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) .
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