DPBQ,7029-89-2

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DPBQ

CAS No. : 7029-89-2

MCE 国际站：DPBQ

产品活性：DPBQ 以多倍体特异性方式激活 p53 并触发凋亡 (apoptosis)，但不抑制拓扑异构酶或结合 DNA。DPBQ 引起 p53 的表达和磷酸化，这种作用是四倍体细胞特有的。

研究领域：Apoptosis

作用靶点：MDM-2/p53  |  Apoptosis

In Vitro: DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ.

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