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- MedChemExpress(MCE)
- 美国
- HY-18650
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
-20°C, sealed storage, away from moisture
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
845932-30-1
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥1590.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥3500.0 |
| 规格： | 10 mg | 产品价格： | ￥5500.0 |
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KU 59403
CAS No. : 845932-30-1
MCE 国际站：KU 59403
产品活性：KU 59403 是 ATM 的一个有效抑制剂，其对 ATM、DNA-PK 和 PI3K 的 IC50 值分别为 3 nM、9.1 μM 和 10 μM。
研究领域：Cell Cycle/DNA Damage | PI3K/Akt/mTOR
作用靶点：ATM/ATR
In Vitro: KU 59403 (1 μM) enhances VP-16 (1 μM) cytotoxicity to a similar extent in HCT116 and HCT116-N7 cells, and in the p53 mutant SW620 cells and human breast cancer cell line, MDAMB-231, sensitisation is 11.9±4.7 and 3.8±1.8-fold respectively. Inhibition of IR-induced ATM activity by KU 59403 (1 μM) is approximately 50% in MDA-MB231 cells and >50% in HCT116 cells that have low ATM expression and activity.
In Vivo: KU59403 with a single daily dose of 12.5 mg/kg causes a significant sensitization.
Increasing the dose of KU59403 to 25 mg/kg given twice daily results in the greatest chemo-sensitisation with a 3-fold increase in BMY-40481-induced tumour growth delay in both SW620 and HCT116-N7 xenografts, in the absence of a significantly increased toxicity.
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