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- 文献和实验
- 技术资料
- 保存条件:
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
865783-95-5
- 规格:
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格: | 10 mM * 1 mL | 产品价格: | ¥1181.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥524.0 |
| 规格: | 5 mg | 产品价格: | ¥1073.0 |
| 规格: | 10 mg | 产品价格: | ¥1688.0 |
| 规格: | 25 mg | 产品价格: | ¥2863.0 |
| 规格: | 50 mg | 产品价格: | ¥4113.0 |
| 规格: | 100 mg | 产品价格: | ¥5750.0 |
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ON-013100
CAS No. : 865783-95-5
MCE 国际站:ON-013100
产品活性:ON-013100,一种抗肿瘤活性分子,作为有丝分裂的抑制剂,能够抑制细胞周期蛋白 D1 (Cyclin D1) 的表达。
研究领域:Cell Cycle/DNA Damage
作用靶点:CDK
In Vitro: ON-013100 induces apoptosis, and has activity against most human cancer cell lines in vitro. ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle. ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI50=6.7-11.2 nM) .
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