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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
LT-171-861
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1429515-59-2
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1633.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥780.0 |
| 规格： | 5 mg | 产品价格： | ￥1720.0 |
| 规格： | 10 mg | 产品价格： | ￥2583.0 |
| 规格： | 25 mg | 产品价格： | ￥4650.0 |
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FN-1501
CAS No. : 1429515-59-2
MCE 国际站：FN-1501
产品活性：FN-1501 是一种有效的 FLT3 和 CDK 抑制剂，对 CDK2/cyclin A，CDK4/cyclin D1，CDK6/cyclin D1 和 FLT3 的 IC50 值分别为 2.47，0.85，1.96, 和 0.28 nM。FN-1501 具有抗肿瘤的活性。
研究领域：Cell Cycle/DNA Damage | Protein Tyrosine Kinase/RTK
In Vitro: FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47 ± 0.21, 0.85 ± 0.28, 1.96 ± 0.08 and 0.28 ± 0.01 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 shows potent inhibitory activity against several tumor cells, such as MGC803, RS4 11, MCF-7, HCT-116, and NCI-H82, with GI50s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively.
In Vivo: FN-1501 exhibits potent antitumor activity, and shows little cytotoxicity on normal lymphocyte cells, with LD50 of 185.67 mg/kg in ICR mice. FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and significantly suppresses the growth of tumor in MV4-11-cell-inoculated-xenograft mice.
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文献和实验acttgtaaac aatgtgctga agcagttgac aagtgtccca tgtgctacac agtcattact 1501 ttcaagcaaa aaatttttat gtcttaatct aactctatag taggcatgtt atgttgttct 1561 tattaccctg attgaatgtg tgatgtgaac tgactttaag taatcaggat tgaattccat 1621 tagcatttgc taccaagtag gaaaaaaaat gtacatggca
help:请各位高手帮忙看看我设计的SD大鼠caspase-3的引物
aagtggtatgtcttagaacttgaatccacgagcagagtcaaaggctggttttggaactga >>>>>>>>>>>>>>>>>>>> 1381 tctgtggaaatgaagagttggagcactgtagcacacattatagctactggttttgtgaca 1441 gttgaccaggtcacatatttattatttaagacaaaagtcgtgttttattattggaacaaa 1501 aataactttatatgagaggaaaaccatgtgtgaacttggttggcttgttgaaggctacca 1561
cagggccgga ccgacccgaa ccagaacacc 1321 gggacgtcca tccaccggtg ccgcgtcgtc ccggcgcccg acctggcgcc cgccgcgaag 1381 cagttcccga cgttcctggg ccggccgtgg aaggagtact cgcggacggt gtacatgctg 1441 tcctacctgg actcgcacgt cgacccgagg ggttggctcg agtggaacgg cgccgacttc 1501
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