Seclidemstat,1423715-37-0

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Seclidemstat

CAS No. : 1423715-37-0

MCE 国际站：Seclidemstat

产品活性：Seclidemstat 是一种有效的非竞争性可逆 KDM1A (LSD1) 抑制剂 (K_i=31 nM, IC₅₀)。Seclidemstat 促进 SWI/SNF 复合物突变卵巢癌的抗肿瘤免疫，并抑制病毒产生、病毒 DNA 复制和晚期基因表达。Seclidemstat 可用于尤文肉瘤的研究。

研究领域：Epigenetics

作用靶点：Histone Demethylase

In Vitro: Seclidemstat (72 hours) inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC₅₀ ranging from 0.013 to 2.819 μM (COV434, BIN67, SCCOHT-1, TOV21G, SKOV3, A427, H522, A549, H1299, G401, G402, HCC15 cells).
?Seclidemstat (72 hours) promotes endogenous retroviruses (ERVs) expression and activation of IFNβ pathway in SCCOHT cell lines (SCCOHT-1, BIN67, and COV434 cells).
?Seclidemstat (3 μM) promotes PD-L1 expression in SCCOHT COV 434 pIND 20 BRG1-2.7 cell line.

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