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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1628208-23-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1387.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥453.0 |
| 规格： | 5 mg | 产品价格： | ￥855.0 |
| 规格： | 10 mg | 产品价格： | ￥1410.0 |
| 规格： | 25 mg | 产品价格： | ￥2650.0 |
| 规格： | 50 mg | 产品价格： | ￥3600.0 |
| 规格： | 100 mg | 产品价格： | ￥5500.0 |
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CPI-455
CAS No. : 1628208-23-0
MCE 国际站：CPI-455
产品活性：CPI-455 是一种特异性的泛 KDM5 抑制剂，对 KDM5A 的 IC50 为 10 nM，CPI-455 介导 KDM5 抑制，提高 H3K4me3 的整体水平，并减少多肿瘤细胞系模型中耐药的持久癌细胞的数量。
研究领域：Epigenetics
作用靶点：Histone Demethylase
In Vitro: CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
CPI-455, with high measured affinity for the target KDM5 proteins. Within 24 hours, increases in H3K4me3, are observed after exposure to either of the two active compounds, CPI-455 and CPI-766, in a dosedependent manner. IC50 calculation for KDM5 Inhibitor CPI0455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively.
In Vivo: Dual blockade of B7-H4 and KDM5B (CPI-455, 50/70 mg/kg, ip, daily) in mice elicits protective immunity.
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文献和实验调查表（California psychologicalinventory,CPI) 由H.G.Gough（1957）编制，经过多次修订（1964－1975），属自陈量表，个别进行。主要用于正常人（13岁以上）的人格调查。 （一）CPI的目的和结构 编制的目的有二：其一，预测人们在一定情境下会如何说如何作；其二，确定对人们作观察时的描述方法，使人们对自己了解得好些。 Gough 在学生时从事过MMPI的工作。他决定编制一个用于正常人的人格调查表。参照MMPI
Assessment of Neurogenesis and White Matter Regeneration
, so it is very important to choose the adequate period to investigate the stimulation of neurogenesis under postischemic condition (Neurol Res 28:461–468, 2006; Brain Res 902:288–293, 2001; J Cereb Blood Flow Metab 22:411–419, 2002; J Cereb Blood Flow Metab 23:331–341
The European Prospective Investigation into Cancer and Nutrition Biobank
or genetic factors as well as other disease end-points. The study includes 521,448 participants (367,993 women and 153,455 men, mostly aged 35–70 years) recruited in 23 centers located in ten European countries, who are followed up for cancer incidence
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