Corin,1808113-09-8

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Corin

CAS No. : 1808113-09-8

MCE 国际站：Corin

产品活性：Corin 是组氨酸赖氨酸特异性去甲基化酶 (LSD1) 和组氨酸脱乙酰化酶 (HDAC) 的双重抑制剂，其对 LSD1 的 K_i(inact) 值为 110 nM，对 HDAC1 的 IC₅₀ 值为 147 nM。

研究领域：Epigenetics  |  Cell Cycle/DNA Damage

作用靶点：Histone Demethylase  |  HDAC

In Vitro: Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC₅₀ 95 nM vs. MS-275 EC₅₀ 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM).

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