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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
AE 3-208
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
402473-54-5
- 规格：
10 mM * 1 mL/1 mg/2 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥916.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥444.0 |
| 规格： | 2 mg | 产品价格： | ￥620.0 |
| 规格： | 5 mg | 产品价格： | ￥1030.0 |
| 规格： | 10 mg | 产品价格： | ￥1600.0 |
| 规格： | 25 mg | 产品价格： | ￥2975.0 |
| 规格： | 50 mg | 产品价格： | ￥4500.0 |
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ONO-AE3-208
CAS No. : 402473-54-5
MCE 国际站：ONO-AE3-208
产品活性：ONO-AE3-208 是一种选择性和口服活性的 EP4 受体拮抗剂，Ki 为 1.3 nM。ONO-AE3-208 对 EP3、FP 和 TP 受体的影响较小 (Ki 分别为 30 nM、790 nM 和 2400 nM)。ONO-AE3-208 抑制前列腺癌的细胞侵袭、迁移和转移。
研究领域：GPCR/G Protein
作用靶点：Prostaglandin Receptor
In Vitro: ONO-AE3-208 surpresses the in vitro cell invasion and migration in a dose-dependent manner without affecting cell proliferation. ONO-AE3-208 abolisheS CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid (AA) causeS dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208.
In Vivo: ONO-AE3-208 surpresses the in vivo bone metastasis of PC3 cells in mice. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls.
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