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- 2026年07月31日
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- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
OPC-21268
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
131631-89-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥990.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥377.0 |
| 规格： | 5 mg | 产品价格： | ￥900.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2000.0 |
| 规格： | 50 mg | 产品价格： | ￥2800.0 |
| 规格： | 100 mg | 产品价格： | ￥4800.0 |
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Fuscoside
CAS No. : 131631-89-5
MCE 国际站：Fuscoside
产品活性：Fuscoside (OPC-21268) 是一种口服有效的非多肽类加压素受体 (vasopressin V1) 拮抗剂， IC50 值为0.4 μM。
研究领域：GPCR/G Protein
作用靶点：Vasopressin Receptor
In Vitro: The concentration of Fuscoside (OPC-21268) that displaces 50% of specific AVP binding (IC50) is 0.4 μM for VI receptors and 100 μM for V2 receptors. The inhibition constant (Ki) of Fuscoside (OPC-21268) for V1 receptors (0.14 μM).
In Vivo: Fuscoside (OPC-21268) competitively and specifically antagonizes pressor responses to AVP in vivo. Oral administration of Fuscoside (OPC-21268) (10 mg/kg) inhibits the vasoconstriction induced by exogenous AVP in a dose- and time-dependent manner and the effect lasts for more than 8 hours at 30 mg/kg. Fuscoside (OPC-21268) predominantly exerts a protective effect in areas where the maximum amount of blood-brain barrier breakdown occurs, and it is effective in the treatment of cold-induced vasogenic brain edema. Fuscoside (OPC-21268) treatment at the dosages of 200 and 300 mg/kg significantly reduces brain water content in both hemispheres. Swelling of the traumatized hemispheres is also significantly reduced at 200 and 300 mg/kg dosages.
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