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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1373765-19-5
- 规格：
1 mg/5 mg/10 mg/25 mg
| 规格： | 1 mg | 产品价格： | ￥240.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥640.0 |
| 规格： | 10 mg | 产品价格： | ￥866.0 |
| 规格： | 25 mg | 产品价格： | ￥1538.0 |
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IPSU
CAS No. : 1373765-19-5
MCE 国际站：IPSU
产品活性：IPSU是一种选择性，有口服活性和脑渗透性的OX2R拮抗剂，pKi值为7.85。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Orexin Receptor (OX Receptor)
In Vitro: Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. IPSU binds rapidly and reaches equilibrium very quickly in binding and/or functional assays.
In Vivo: IPSU has low blood clearance, shows high maximal blood exposure and AUC after oral dosing. It exhibits an acceptable absolute oral bioavailability and a brain/blood concentration ratio that indicated favorable brain penetration. IPSU increases sleep when dosed during the mouse active phase (lights off); IPSU induces sleep primarily by increasing NREM sleep. IPSU shows a fast onset of action, with a clear increase in total sleep time during the first hour afterdosing. The effect lasts 4-5 h, after which time the total sleep time per hour is the same as on vehicle day .
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文献和实验μL 体系 2× MasterMix 25 μL 上游 Primer （ 10 μM 1-5 μL 下游 Primer （ 10 μM ） 1-5 μL 模板 lamid DNA ～ 50 ng genomic DNA ～ 1000 ng cDNA ～ 500 ng 粗提液 ～ 2 μL 灭菌蒸馏水至 50 μL PCR 扩增实例： 一、plasmid DNA 扩增 1．提取的质粒 DNA 扩增 以pUC19 质粒为模板扩增 100，250，500
, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020, 395(10229):1033-1034. 6. David J M Wright. Prevention of the cytokine storm in COVID-19. Lancet Infect Dis. 2020. doi: 10.1016/S1473-3099(20)30376-5
的E.coli 接种于30-50ml LB/抗生素培养液中，37°C搖床培养12~16 h； 2. 取30-50ml的菌液，室温下3，500-5，000xg离心10min收集细菌。 3. 倒弃培养基。加入2.5ml Solution I/RNaseA混和液，漩涡振荡使细胞完全悬浮。 4. 往重悬混和液中加入2.5ml Solution Ii，轻轻颠倒混匀7-10次后可将混合液室温放置2min以提高产量。避免剧烈混和裂解液且裂解反应不要超过5 min。
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