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- 2025年07月16日
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- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
MIW815 ammonium salt; ML RR-S2 CDA ammonium salt
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1638750-96-5
- 规格：
1 mg
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ADU-S100 ammonium salt
CAS No. : 1638750-96-5
MCE 国际站：ADU-S100 ammonium salt
产品活性：ADU-S100 ammonium salt (MIW815 ammonium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。
作用靶点：STING
In Vitro: ADU-S100 ammonium salt has several features that improve both stability and lipophilicity, promoting significantly increased STING signaling as compared to endogenous and pathogen-derived cyclic dinucleotides (CDNs).
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTINGREF and hSTINGQ alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
In Vivo: ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%.
相关产品：CCCP | H-151 | Vadimezan | C-176 | 2',3'-cGAMP sodium | MSA-2 | ADU-S100 disodium salt | Omaveloxolone | SN-011 | SR-717 | diABZI STING agonist-1 trihydrochloride | cGAMP disodium | c-di-AMP disodium | STING-IN-2 | STING agonist-3 | Cyclic-di-GMP diammonium | STING agonist-1 | C-178 | IACS-8803 disodium | STING agonist-4 | PROTAC STING Degrader-1 | STING-IN-3 | diABZI-C2-NH2 | E7766 diammonium salt | SN-001 | STING agonist-12
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