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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
MIW815 disodium salt; ML RR-S2 CDA disodium salt
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1638750-95-4
- 规格：
1 mg
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ADU-S100 disodium salt
CAS No. : 1638750-95-4
MCE 国际站：ADU-S100 disodium salt
产品活性：ADU-S100 disodium salt (MIW815 disodium salt) 是干扰素基因刺激物的激活剂 (STING)，具有有效的抗肿瘤和免疫活性。
作用靶点：STING
In Vitro: ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTINGREF and hSTINGQ alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
In Vivo: ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%.
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文献和实验Assembly of Nucleosomal Templates by Salt Dialysis
Because it is convenient to assemble nucleosomal templates through salt dialysis, large amounts of chromatin complexes can be made easily and in a short amount of time. This unit includes instructions for the various salt dialysis schemes (step versus gradient
Preparation of nuclear extract and cytoplasmic extract
Solutions:Buffer A (Hypotonic Buffer): 1L10 mM HEPES pH 7.9 10 ml 1M HEPES,pH 7.91.5 mM MgCl2 1.5 ml 1M MgCl210 mM KCl3.33 ml 3M KCl0.5 mM DTT 500 µl 1M DTT0.2 mM PMSF 1 ml 0.2 M PMSFBuffer B (S100 extraction buffer): 500 ml0.3 M HEPES pH 7.9 150 ml
Preparation of nuclear extract and cytoplasmic extract
at 2000 rpm for 15 minutes in J-6 to pellet nuclei. 6. Save the supernatant for S100 extract (see below). 7. Transfer the nuclear pellet to a glass beaker containing a stir bar and add 1/2 packed nuclear volume of Low Salt Buffer.
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