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- 详细信息
- 技术资料
- 保存条件:
Powder: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名:
Cyclic GMP-AMP; 3',3'-cGAMP
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
849214-04-6
- 规格:
500 μg/1 mg
| 规格: | 500 μg | 产品价格: | ¥1900.0 |
|---|---|---|---|
| 规格: | 1 mg | 产品价格: | ¥3300.0 |
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cGAMP
CAS No. : 849214-04-6
MCE 国际站:cGAMP
产品活性:cGAMP (Cyclic GMP-AMPP) 作为内源性第二信使发挥作用,并触发干扰素的产生以响应胞浆DNA。cGAMP 激活干扰素基因刺激因子 (STING),激活导致产生 I 型干扰素和其他免疫介质的信号级联。
作用靶点:STING
In Vitro: cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice.
cGAMP directly activates murine and human dendritic cells in vitro.
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF).
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs.
In Vivo: cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice.
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