Belvarafenib,1446113-23-0

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Belvarafenib

CAS No. : 1446113-23-0

MCE 国际站：Belvarafenib

产品活性：Belvarafenib (HM95573) 是一种有效的，广泛的迅速加速纤维肉瘤激酶 (RAF) 的抑制剂，其对 B-RAF，B-RAF^v600E 和C-RAF 的 IC₅₀ 值分别为 56 nM, 7 nM 和 5 nM。

研究领域：MAPK/ERK Pathway

作用靶点：Raf

In Vitro: Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC₅₀ values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv^600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC₅₀s of 10 nM, 23 nM and 44 nM, respectively.

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