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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
2035509-96-5
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1423.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥621.0 |
| 规格： | 5 mg | 产品价格： | ￥997.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3600.0 |
| 规格： | 50 mg | 产品价格： | ￥5040.0 |
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AX-15836
CAS No. : 2035509-96-5
MCE 国际站：AX-15836
产品活性：AX-15836是有效，选择性的ERK5抑制剂，IC50值为8 nM。
研究领域：MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点：ERK
In Vitro: AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. It also exhibits selectivity over BRD4 with a Kd of 3,600 nM. AX15836 shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. AX15836 was completely ineffective (EC50>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells.
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文献和实验。 MTT法――活性测定 1、接种细胞：用0.25%胰蛋白酶消化单层培养细胞，用含10%胎牛血清的RPMI1640培养液配成单个细胞悬液，以每孔103-104个细胞接种于96孔板中，每孔体积200μl。 2、培养细胞：将培养板移入CO2培养箱中，在37℃、5%CO2及饱和湿度条件下，培养3-5天。（培养时间取决于实验目的和要求） 3、呈色：培养第3-5天后，每孔加入MTT溶液（5mg/ml）20μl，37℃，继续孵育4h，终止培养，小心吸弃孔内培养液上清。每孔加入150μlDMSO（二甲
M73206 96% N,N’-diisopropylcarbodiimide Chem-Impex 001100 99.5%
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