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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
Lignocaine hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
73-78-9
- 规格：
10 mM * 1 mL/500 mg/5 g/10 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥400.0 |
| 规格： | 5 g | 产品价格： | ￥500.0 |
| 规格： | 10 g | 产品价格： | ￥800.0 |
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Lidocaine hydrochloride
CAS No. : 73-78-9
MCE 国际站：Lidocaine hydrochloride
产品活性：Lidocaine (Lignocaine) hydrochloride 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的活性分子和有效的肿瘤抑制剂。
研究领域：Membrane Transporter/Ion Channel | MAPK/ERK Pathway | Stem Cell/Wnt | NF-κB | Apoptosis
作用靶点：Sodium Channel | MEK | ERK | NF-κB | Apoptosis
In Vitro: Lidocaine hydrochloride (Lignocaine hydrochloride) (10 nM; 48 hours) decreases significantly cell proliferation.
Lidocaine hydrochloride (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10 nM and treatment time 48 hours.
Lidocaine hydrochloride (10 nM; 48 hours) increases significantly the apoptotic cell rate.
Lidocaine hydrochloride (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.
In Vivo: Lidocaine hydrochloride (Lignocaine hydrochloride) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block.
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文献和实验4.32 3.72 3.38 3.15 2.99 2.87 2.78 2.70 2.64 2.54 2.44 2.33 2.21 2.08 1.93 24 25 4.29 3.69 3.35 3.13 2.97 2.85 2.75 2.68 2.61 2.51 2.41 2.30 2.18 2.05 1.91 25 26 4.26 3.67 3.33 3.10 2.94 2.82 2.73 2.65 2.59 2.49 2.39 2.28 2.16 2.03 1.88 26
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2.13 2.07 2.03 1.95 1.89 1.85 1.81 1.78 50 60 4.00 3.15 2.76 2.53 2.37 2.25 2.17 2.10 2.04 1.99 1.92 1.86 1.82 1.78 1.75 60 80 3.96 3.11 2.72 2.49 2.33 2.21 2.13 2.06 2.00 1.95 1.88 1.82 1.77 1.73 1.70 80 100 3.94 3.09 2.70 2.46 2.31 2.19 2.10 2.03
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