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- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
(±)-Verapamil hydrochloride; CP-16533-1 hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
152-11-4
- 规格：
10 mM * 1 mL/500 mg/1 g/5 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥500.0 |
|---|---|---|---|
| 规格： | 500 mg | 产品价格： | ￥400.0 |
| 规格： | 1 g | 产品价格： | ￥520.0 |
| 规格： | 5 g | 产品价格： | ￥1520.0 |
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Verapamil hydrochloride
CAS No. : 152-11-4
MCE 国际站：Verapamil hydrochloride
产品活性：Verapamil hydrochloride ((±)-Verapamil hydrochloride) 是一种钙通道 (calcium channel) 阻滞剂，是一种有效的口服活性的第一代 P 糖蛋白 (P-gp) 抑制剂。Verapamil hydrochloride 能也抑制 CYP3A4，并可用于高血压，心律不齐和心绞痛的研究。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease
作用靶点：Calcium Channel | P-glycoprotein | Cytochrome P450
In Vitro: The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM.
In Vivo: Given orally Verapamil is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation.
Verapamil is injected i.v. into a femoral vein prior to ischemia. Verapamil (1 mg/kg) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia.
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