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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SJ000557733
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1424799-20-1
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥4895.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1900.0 |
| 规格： | 5 mg | 产品价格： | ￥4750.0 |
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(+)-SJ733
CAS No. : 1424799-20-1
MCE 国际站：(+)-SJ733
产品活性：(+)-SJ733 是一种抗疟疾剂，也是一个 Na+-ATPase PfATP4 抑制剂。
研究领域：Membrane Transporter/Ion Channel | Anti-infection
作用靶点：Na+/K+ ATPase | Parasite
In Vitro: (+)-SJ733 binds to a single receptor site in P. falciparum-infected erythrocytes with equivalent affinity to its growth-inhibitory potency (kd=50 nM). (+)-SJ733 has not exhibited either significant safety liabilities at any dose in extensive profiling in vitro or significant safety or tolerability liabilities in either single- or repeat-dose studies at any dose tested in any preclinical species (no observed adverse effect level and maximum tolerated dose >240 mg/kg from 7-d repeat dosing study in rat). Therefore, (+)-SJ733 is expected to have a safety margin of at least 43-fold.
In Vivo: Treatment of P. falciparum-infected NOD-scid IL2Rγnull mice with (+)-SJ733 causes rapid clearance of parasites, which are 80% depleted within the first 24 h and undetectable by 48 h. (+)-SJ733 is highly potent and efficacious against P. falciparum 3D70087/N9 in vivo when administered as four sequential daily oral doses in the NOD-scid IL2Rγnull mouse model, with a 90% effective dose, (ED90 1.9 mg/kg) and exposure [area under the curve at ED90 (AUCED90), 1.5 μM⋅h] superior to artesunate (11.1 mg/kg; AUCED90 not determined), chloroquine (4.3 mg/kg; AUCED90 3.1 μM⋅h), and pyrimethamine (0.9 mg/kg; AUCED90 5. μM⋅h) in the same model. When treated with the ED90 dose, (+)-SJ733 concentrations in blood remain above the average in vitro EC90 for 6 to 10 h after each dose.
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文献和实验In Situ Hybridization Using Digoxigenin Labeled Probes
(I prefer overnight but if you're in a hurry, 3 hours should give a nice probe) 5) Add 20 ug carrier DNA and 1/10 volume 3M NaOAc. Precipitate with 2.5 volumes EtOH for 1 hr @ -70oC or overnight @ -20oC 6) Spin DNA in microfuge 15 min. Remove EtOH
with a pipette. Insert the teeth of the comb approximately 1 mm into the gel. Pre-heat the gel at 1700 volts for 15-20 minutes. F: Gel Loading Remove the samples from the freezer. Denature the samples in a thermal cycler at 95°C for 5 mins. Remove
by adding ammonium acetate (pH 7.0) to 3 M. 11.Precipitate the DNA with three volumes of ethanol, centrifuge for 10 min (14,000 rev/min) at room temperature, wash twice with 70% ethanol and dry under a vacuum. Resuspend in 50 µl TE, and store at -20
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